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It is in the northeastern part of the state and the northern part of Florence County.
The average elevation above sea level is around 140 ft (43 m).
Companies with regional operations and headquarters include BB&T, Monster.com, Otis Elevator, CSX Railway, Wells Fargo and Bank of America.
Florence has blossomed into a strong center for medical care, with four major medical providers Mc Leod Regional Medical Center, Carolinas Hospital System, Regency Hospital and Health South.
The growth of these providers has led to the transformation of the Florence skyline over the last 10 years, with development for demand with multi-story high-rises as well as community relation projects.
The Florence Public School District One is the governing body of the public schools in the area.
As of 2010, the district has an active enrollment of 14,500 students, attending a total of 18 schools, including 12 elementary schools, three middle schools, and three high schools serving the City of Florence, Effingham and Quinby areas.